Abstract |
Community-acquired Staphylococcus aureus infections are a public health concern, yet little is known about infections that do not present to hospital. We identified community-onset S. aureus infections via specimens submitted to a community-based pathology service. Referring doctors confirmed eligibility and described infection site, severity and treatment. Isolates were characterized on antibiotic resistance, PFGE, MLST/SCCmec, and Panton-Valentine leukocidin (PVL), representing 106 community-onset infections; 34 non-multiresistant methicillin-resistant S. aureus (nmMRSA) (resistant to <3 non-β- lactam antibiotics), 15 multiply antibiotic-resistant MRSA (mMRSA) and 57 methicillin-sensitive S. aureus (MSSA). Most (93%) were skin and soft tissue infections. PVL genes were carried by 42% of nmMRSA isolates [95% confidence interval (CI) 26-61] and 15% of MSSA (95% CI 8-28). PVL was associated with infections of the trunk, head or neck (56·4% vs. 24·3%, P=0·005) in younger patients (23 vs. 52 years, P<0·001), and with boils or abscesses (OR 8·67, 95% CI 2·9-26·2), suggesting underlying differences in exposure and/or pathogenesis.
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Authors | C M Bennett, G W Coombs, G M Wood, B P Howden, L E A Johnson, D White, P D R Johnson |
Journal | Epidemiology and infection
(Epidemiol Infect)
Vol. 142
Issue 3
Pg. 501-11
(Mar 2014)
ISSN: 1469-4409 [Electronic] England |
PMID | 23866772
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Anti-Bacterial Agents
(pharmacology)
- Community-Acquired Infections
(drug therapy, epidemiology, microbiology)
- Drug Resistance, Bacterial
- Humans
- Methicillin-Resistant Staphylococcus aureus
(isolation & purification, pathogenicity)
- Middle Aged
- Polymerase Chain Reaction
- Prevalence
- Severity of Illness Index
- Staphylococcal Infections
(drug therapy, epidemiology, microbiology)
- Staphylococcus aureus
(isolation & purification, pathogenicity)
- Victoria
(epidemiology)
- Virulence
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