Estimation of perilymph enhancement after intratympanic administration of Gd-DTPA by fast T₁-mapping with a dual flip angle 3D spoiled gradient echo sequence.

Abstract

Eleven patients with suspected Ménière's disease received intratympanic (IT) administration of gadolinium (gadopentetate dimeglumine; Gd) prior to acquisition of 3-dimensional (3D) fluid-attenuated inversion recovery (FLAIR), 3D real inversion recovery (IR), and fast T₁ mapping by dual flip angle 3D gradient echo (FT₁-map) imaging sequences to evaluate the degree of perilymph enhancement. Though 3-dimensional FLAIR could detect lower concentrations of gadolinium than 3D real IR, in 2 patients, poor enhancement still prevented visualization of the endolymphatic space using 3D FLAIR. We could predict poor contrast enhancement in these 2 patients using the FT₁-map technique.

• Authors: Shinji Naganawa, Masahiro Yamazaki, Hisashi Kawai, Kiminori Bokura, Michihiko Sone, Tsutomu Nakashima
• Journal: Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine (Magn Reson Med Sci) Vol. 12 Issue 3 Pg. 223-8 ( 2013) ISSN: 1880-2206 [Electronic] Japan
• PMID: 23857148 (Publication Type: Journal Article)

Chemical References

• Contrast Media
• Gadolinium DTPA

Topics

• Adult
• Aged
• Algorithms
• Contrast Media (administration & dosage)
• Female
• Gadolinium DTPA (administration & dosage)
• Humans
• Image Enhancement (methods)
• Image Interpretation, Computer-Assisted (methods)
• Imaging, Three-Dimensional (methods)
• Magnetic Resonance Imaging (methods)
• Male
• Meniere Disease (pathology)
• Middle Aged
• Perilymph (cytology)
• Reproducibility of Results
• Sensitivity and Specificity
• Tympanic Membrane (drug effects, pathology)