Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP.

Abstract

MicroRNA has been recently recognized as playing a prominent role in tumorigenesis and metastasis. Here, we report that miR-338-3p was epigenetically silenced in gastric cancer, and its down-regulation was significantly correlated with gastric cancer clinicopathological features. Strikingly, restoring miR-338-3p expression in SGC-7901 gastric cancer cells inhibited proliferation, migration, invasion and tumorigenicity in vitro and in vivo, at least partly through inducing apoptosis. Furthermore, we demonstrate the oncogene SSX2IP is a target of miR-338-3p. We propose that miR-338-3p functions as a tumor suppressor in gastric cancer, and the methylation status of its CpG island could serve as a potential diagnostic marker for gastric cancer.

• Authors: Pu Li, Xuehua Chen, Liping Su, Chenglong Li, Qiaoming Zhi, Beiqin Yu, Hong Sheng, Junqing Wang, Runhua Feng, Qu Cai, Jianfang Li, Yingyan Yu, Min Yan, Bingya Liu, Zhenggang Zhu
• Journal: PloS one (PLoS One) Vol. 8 Issue 6 Pg. e66782 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 23826132 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• MIRN338 microRNA, human
• MicroRNAs
• Neoplasm Proteins
• Repressor Proteins
• synovial sarcoma X breakpoint proteins

Topics

• Animals
• Cell Line, Tumor
• Epigenesis, Genetic (genetics)
• Humans
• Immunohistochemistry
• Male
• Mice
• Mice, Nude
• MicroRNAs (genetics)
• Neoplasm Proteins (genetics, metabolism)
• Repressor Proteins (genetics, metabolism)
• Stomach Neoplasms (genetics, metabolism, therapy)
• Xenograft Model Antitumor Assays