[Antimetastatic effect of L-lysine-alpha oxidase].

Abstract

The influence of a new antitumor enzyme L-lysine alpha-oxidase on Lewis lung carcinoma spreading was studied in mice in which primary tumor had been removed. The enzyme was found to significantly decrease the extent and number of lung metastases as compared to mice which hadn't received L-lysine alpha-oxidase. This was matched by recovery of alveolar macrophages functional activity, as assessed by adenosine deaminase and 5' nucleotidase levels in these cells. Moreover, antimetastatic and cytostatic effect was confirmed by the measuring of polyamine concentration in mice erythrocytes.

• Authors: V Iu Umanskiĭ, S Kh Khaduev, S P Zaletok, K P Balitskiĭ, N K Berdinskikh, T T Berezov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 109 Issue 5 Pg. 458-9 (May 1990) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Antimetastaticheskiĭ éffekt L-lizin-alfa-oksidazy.
• PMID: 2378955 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Polyamines
• Amino Acid Oxidoreductases
• L-lysine oxidase
• 5'-Nucleotidase
• Adenosine Deaminase

Topics

• 5'-Nucleotidase (analysis)
• Adenosine Deaminase (analysis)
• Amino Acid Oxidoreductases (therapeutic use)
• Animals
• Chromatography
• Erythrocytes (analysis)
• Lung Neoplasms (surgery)
• Macrophages (analysis)
• Mice
• Mice, Inbred C57BL
• Neoplasm Metastasis (prevention & control)
• Polyamines (blood)
• Pulmonary Alveoli (analysis)