Abstract | BACKGROUND: METHOD: Baseline psychotropic medication use rates were compared in two research cohorts of patients at high risk for psychosis that enrolled between 1998-2005 (n=391) and 2008-2011 (n=346). Treatment durations and antipsychotic doses were described for cohort 2. RESULTS: Median age was 17years in cohort 1 and 18years in cohort 2. The rate of prescription of any psychotropic at baseline was roughly 40% for each cohort. Antipsychotic prescription rates were 24% among sites that permitted baseline antipsychotic use in cohort 1 and 18% in the cohort 2; the decline did not quite reach statistical significance (p=0.064). In cohort 2 the mean±SD baseline chlorpromazine-equivalent dose was 121±108mg/d, and lifetime duration of antipsychotic treatment was 3.8±5.9months. DISCUSSION: Although the rate of antipsychotic prescription among high-risk youth may have fallen slightly, the nearly one-in-five rate in the second cohort still constitutes a significant exposure. Mitigating factors were that doses and durations of treatment were low. As for other nonpsychotic conditions, it is incumbent on our field to develop alternative treatments for high-risk patients and to generate additional evidence for or against the efficacy of antipsychotics to help define their appropriate role if alternative treatments fail.
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Authors | Scott W Woods, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Daniel H Mathalon, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Thomas H McGlashan |
Journal | Schizophrenia research
(Schizophr Res)
Vol. 148
Issue 1-3
Pg. 99-104
(Aug 2013)
ISSN: 1573-2509 [Electronic] Netherlands |
PMID | 23787224
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2013 Elsevier B.V. All rights reserved. |
Chemical References |
- Antipsychotic Agents
- Psychotropic Drugs
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Topics |
- Adolescent
- Antipsychotic Agents
(therapeutic use)
- Chi-Square Distribution
- Cohort Studies
- Female
- Humans
- Male
- Prescriptions
- Psychotic Disorders
(drug therapy)
- Psychotropic Drugs
(therapeutic use)
- Retrospective Studies
- Risk
- Statistics, Nonparametric
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