Abstract | OBJECTIVE: DESIGN: Observational nonrandomised 1-year prospective cohort study. SETTING: Fifty-three hospitals in Finland. POPULATION: METHODS: MAIN OUTCOME MEASURES: RESULTS:
Cefuroxime had a risk-reductive effect for total infections (adjusted odds ratio, OR, 0.29; 95% confidence interval, 95% CI, 0.22-0.39), but the independent effect of metronidazole and the interaction effect of cefuroxime and metronidazole were nonsignificant. In subgroup analyses of AHs, LHs, and VHs involving those receiving the two main antibiotics only, the effect of cefuroxime alone nonsignificantly differed from that of cefuroxime and metronidazole in combination for all types of infection. The absence of cefuroxime, assessed by comparing metronidazole alone with cefuroxime and metronidazole in combination, led to an increased risk for total infections in AHs (adjusted OR 3.63; 95% CI 1.99-6.65), in LHs (OR 3.53; 95% CI 1.74-7.18), and in VHs (OR 4.05; 95% CI 2.30-7.13), and also increased risks for febrile events in all categories (AHs, OR 2.86; 95% CI 1.09-7.46; LHs, OR 13.19; 95% CI 3.66-47.49; VHs, OR 12.74; 95% CI 3.01-53.95), wound infections in AHs (OR 6.88; 95% CI 1.09-7.49), and pelvic infections in VHs (OR 4.26; 95% CI 1.76-10.31). CONCLUSIONS:
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Authors | T H I Brummer, A-M Heikkinen, J Jalkanen, J Fraser, J Mäkinen, E Tomás, T Seppälä, J Sjöberg, P Härkki |
Journal | BJOG : an international journal of obstetrics and gynaecology
(BJOG)
Vol. 120
Issue 10
Pg. 1269-76
(Sep 2013)
ISSN: 1471-0528 [Electronic] England |
PMID | 23786166
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 RCOG. |
Chemical References |
- Anti-Bacterial Agents
- Metronidazole
- Cefuroxime
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Topics |
- Anti-Bacterial Agents
(therapeutic use)
- Antibiotic Prophylaxis
- Bacterial Infections
(prevention & control)
- Cefuroxime
(therapeutic use)
- Confidence Intervals
- Drug Therapy, Combination
- Female
- Humans
- Hysterectomy, Vaginal
(adverse effects)
- Laparoscopy
- Logistic Models
- Metronidazole
(therapeutic use)
- Odds Ratio
- Pelvis
- Surgical Wound Infection
(prevention & control)
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