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Effects of supplementing different ratios of omega-3 and omega-6 fatty acids in western-style diets on cow's milk protein allergy in a mouse model.

AbstractSCOPE:
This study investigated the effects of supplementing different ratios of omega-6 and omega-3 fatty acids (O6H = 10:1, O3O6 = 4:1, and O3H = 1:4) to western-style diets on cow β-lactoglobulin (BLG) induced allergic reactions in Balb/c mice.
METHODS AND RESULTS:
Three-week-old mice were randomly assigned to three diet groups (n = 20/group). At 9 wk of age, half of the mice from each dietary treatment (n = 10) were intraperitoneally (i.p.) sensitized with three weekly doses of BLG and alum while the remaining half from each group was sham sensitized (controls). One week after the final sensitization, all mice were orally challenged with BLG. Elevated BLG-specific serum Igs were observed in all sensitized and challenged mice. IFN-γ, MCP-1, and IL-12p40 concentrations from lymphocytes of mesenteric lymph nodes were highest in O3H mice, compared to O3O6 and O6H mice. O6H mice had the highest IL-4 concentrations from splenic lymphocytes and a significantly lower rectal temperature after the challenge in comparison to O3O6 and O3H mice.
CONCLUSIONS:
Our results suggest that the ω-3 PUFA rich diets alleviated the severity of allergic reactions, and may modulate immune response toward T helper cell (Th)1-favoured immune response while the ω-6 PUFA rich diet exhibited no allergy alleviation with a stronger Th2 polarized immune response.
AuthorsCin L Thang, Joyce I Boye, Hai Ning Shi, Xin Zhao
JournalMolecular nutrition & food research (Mol Nutr Food Res) Vol. 57 Issue 11 Pg. 2029-38 (Nov 2013) ISSN: 1613-4133 [Electronic] Germany
PMID23780918 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Chemical References
  • Basic Helix-Loop-Helix Transcription Factors
  • Ccl2 protein, mouse
  • Chemokine CCL2
  • Fatty Acids, Omega-3
  • Fatty Acids, Omega-6
  • Hand1 protein, mouse
  • Immunoglobulin A
  • Lactoglobulins
  • Interleukin-12
  • Interleukin-4
  • Immunoglobulin E
  • Interferon-gamma
Topics
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors (immunology, metabolism)
  • Chemokine CCL2 (blood, immunology)
  • Diet
  • Dietary Supplements
  • Disease Models, Animal
  • Fatty Acids, Omega-3 (administration & dosage, blood)
  • Fatty Acids, Omega-6 (administration & dosage, blood)
  • Female
  • Immunoglobulin A (blood, immunology)
  • Immunoglobulin E (blood, immunology)
  • Interferon-gamma (blood, immunology)
  • Interleukin-12 (blood, immunology)
  • Interleukin-4 (immunology, metabolism)
  • Lactoglobulins (immunology)
  • Mice
  • Mice, Inbred BALB C
  • Milk Hypersensitivity (immunology, prevention & control)
  • Spleen (immunology, metabolism)

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