Abstract | BACKGROUND/AIMS: Impaired left ventricular diastolic function and increased left ventricular filling pressure are frequently noted in patients with chronic kidney disease (CKD), even in early stages. The association of increased left ventricular filling pressure with cardiovascular and renal outcomes remains uncertain in CKD. This study is designed to assess whether the ratio of transmitral E-wave velocity (E) to early diastole mitral velocity (Ea) is associated with cardiovascular events and progression to dialysis in patients with CKD stages 3-5. METHODS: RESULTS: The high E/Ea was independently associated with old age, cerebrovascular disease, congestive heart failure, high systolic blood pressure, hypertriglyceridemia, low hemoglobin, proteinuria, and worse echocardiographic profiles. Besides, the high E/Ea increased the risk of cardiovascular events (hazard ratio (HR) 1.067; 95% confidence interval (CI) 1.017-1.119; p = 0.008) and progression to dialysis (HR 1.042; 95% CI 1.000-1.085; p = 0.048). CONCLUSIONS: Our study in patients of CKD stages 3-5 demonstrated the high E/Ea was associated with increased cardiovascular events and progression to dialysis. Assessment of the E/Ea by Doppler echocardiography is useful for predicting the risk of adverse cardiovascular and renal outcomes in CKD patients.
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Authors | Szu-Chia Chen, Jer-Ming Chang, Yi-Chun Tsai, Jiun-Chi Huang, Ling-I Chen, Ho-Ming Su, Shang-Jyh Hwang, Hung-Chun Chen |
Journal | Nephron. Clinical practice
(Nephron Clin Pract)
Vol. 123
Issue 1-2
Pg. 52-60
( 2013)
ISSN: 1660-2110 [Electronic] Switzerland |
PMID | 23774331
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2013 S. Karger AG, Basel. |
Topics |
- Age Distribution
- Comorbidity
- Echocardiography
(statistics & numerical data)
- Female
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Mitral Valve
(diagnostic imaging)
- Prevalence
- Renal Dialysis
(mortality)
- Renal Insufficiency, Chronic
(mortality, rehabilitation)
- Reproducibility of Results
- Risk Assessment
- Sensitivity and Specificity
- Sex Distribution
- Survival Rate
- Taiwan
(epidemiology)
- Ventricular Dysfunction, Left
(diagnostic imaging, mortality)
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