Abstract |
Synaptic plasticity is important for functional recovery after cerebral ischemic injury. In the present study, we investigated chronological change in the immunoreactivity of PSD-95, a kind of postsynaptic density protein, in the hippocampus proper (CA1-3 regions) after 5 min of transient cerebral ischemia in gerbils. PSD-95 immunoreactivity was observed in MAP-2-immunoreactive dendrites in the CA1-3 regions of the sham group. The PSD-95 immunoreactivity was shown as beaded structure in the MAP-2-immunoreactive dendrites. However, PSD-95 immunoreactivity began to be dramatically decreased in MAP-2-immunoreactive dendrites in the CA1 region, not CA2-3 region, at early time after ischemia-reperfusion. At 5 days after ischemia-reperfusion, MAP-2 immunoreactivity almost disappeared in the ischemic CA1 region, and PSD-95 immunoreactivity was much lower than that in the sham group. In brief, PSD-95 immunoreactivity in the CA1 dendrites was markedly decreased at early time after ischemia-reperfusion. We suggest that decreased PSD-95 immunoreactivity in the ischemic CA1 region may lead to a deficit of postsynaptic plasticity in the brain.
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Authors | Bing Chun Yan, Joon Ha Park, Ji Hyeon Ahn, Jae-Chul Lee, Moo-Ho Won, Il-Jun Kang |
Journal | Journal of the neurological sciences
(J Neurol Sci)
Vol. 330
Issue 1-2
Pg. 111-6
(Jul 15 2013)
ISSN: 1878-5883 [Electronic] Netherlands |
PMID | 23684672
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier B.V. All rights reserved. |
Chemical References |
- Fluoresceins
- Fluorescent Dyes
- Nerve Tissue Proteins
- fluoro jade
- postsynaptic density proteins
- Mitogen-Activated Protein Kinase 1
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Topics |
- Animals
- Blotting, Western
- CA1 Region, Hippocampal
(metabolism, pathology)
- Fluoresceins
- Fluorescent Antibody Technique, Indirect
- Fluorescent Dyes
- Gerbillinae
- Immunohistochemistry
- Ischemic Attack, Transient
(metabolism, pathology)
- Male
- Mitogen-Activated Protein Kinase 1
(metabolism)
- Nerve Tissue Proteins
(biosynthesis, genetics)
- Neurons
(pathology)
- Reperfusion Injury
(metabolism, pathology)
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