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Postsynaptic density protein (PSD)-95 expression is markedly decreased in the hippocampal CA1 region after experimental ischemia-reperfusion injury.

Abstract
Synaptic plasticity is important for functional recovery after cerebral ischemic injury. In the present study, we investigated chronological change in the immunoreactivity of PSD-95, a kind of postsynaptic density protein, in the hippocampus proper (CA1-3 regions) after 5 min of transient cerebral ischemia in gerbils. PSD-95 immunoreactivity was observed in MAP-2-immunoreactive dendrites in the CA1-3 regions of the sham group. The PSD-95 immunoreactivity was shown as beaded structure in the MAP-2-immunoreactive dendrites. However, PSD-95 immunoreactivity began to be dramatically decreased in MAP-2-immunoreactive dendrites in the CA1 region, not CA2-3 region, at early time after ischemia-reperfusion. At 5 days after ischemia-reperfusion, MAP-2 immunoreactivity almost disappeared in the ischemic CA1 region, and PSD-95 immunoreactivity was much lower than that in the sham group. In brief, PSD-95 immunoreactivity in the CA1 dendrites was markedly decreased at early time after ischemia-reperfusion. We suggest that decreased PSD-95 immunoreactivity in the ischemic CA1 region may lead to a deficit of postsynaptic plasticity in the brain.
AuthorsBing Chun Yan, Joon Ha Park, Ji Hyeon Ahn, Jae-Chul Lee, Moo-Ho Won, Il-Jun Kang
JournalJournal of the neurological sciences (J Neurol Sci) Vol. 330 Issue 1-2 Pg. 111-6 (Jul 15 2013) ISSN: 1878-5883 [Electronic] Netherlands
PMID23684672 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
Chemical References
  • Fluoresceins
  • Fluorescent Dyes
  • Nerve Tissue Proteins
  • fluoro jade
  • postsynaptic density proteins
  • Mitogen-Activated Protein Kinase 1
Topics
  • Animals
  • Blotting, Western
  • CA1 Region, Hippocampal (metabolism, pathology)
  • Fluoresceins
  • Fluorescent Antibody Technique, Indirect
  • Fluorescent Dyes
  • Gerbillinae
  • Immunohistochemistry
  • Ischemic Attack, Transient (metabolism, pathology)
  • Male
  • Mitogen-Activated Protein Kinase 1 (metabolism)
  • Nerve Tissue Proteins (biosynthesis, genetics)
  • Neurons (pathology)
  • Reperfusion Injury (metabolism, pathology)

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