A case series of de novo inflammatory bowel disease after kidney transplantation.

Abstract

Diarrhea, which is common after transplantation, may be due to infections and immunosuppressive therapy. Inflammatory bowel disease (IBD) de novo or as an exacerbation of pre-existent disease is a rare complication after kidney transplantation with pre-existing disease having a less aggressive clinical course than the de novo disease. Cytomegalovirus mismatch, prescription of tacrolimus instead of cyclosporine or mycophenolate mofetil rather than azathioprine as well as low-dose corticosteroid treatments have been linked to an increased incidence of IBD. This series of renal transplant recipients with de novo IBD showed a higher incidence and more aggressive course than that previously described, possibly related to increased use of tacrolimus with minimization of steroids.

• Authors: P Azevedo, C Freitas, P Aguiar, H Silva, T Santos, P Farrajota, M Almeida, S Pedroso, L S Martins, L Dias, R Vizcaíno, A Castro Henriques, A Cabrita
• Journal: Transplantation proceedings (Transplant Proc) Vol. 45 Issue 3 Pg. 1084-7 (Apr 2013) ISSN: 1873-2623 [Electronic] United States
• PMID: 23622632 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Immunosuppressive Agents

Topics

• Adult
• Female
• Humans
• Immunosuppressive Agents (adverse effects)
• Inflammatory Bowel Diseases (chemically induced)
• Kidney Transplantation
• Male
• Middle Aged