Hypofractionated stereotactic radiotherapy with the hypoxic sensitizer AK-2123 (sanazole) for reirradiation of brain metastases: a preliminary feasibility report.
|
| Abstract |
Reirradiation is a challenging field in the treatment of recurrent brain metastases. Because of the elevated risk of radiation toxicity due to previous irradiation, only a limited dose is prescribed. To enhance radiosensitivity, in the present analysis six patients received hypofractionated stereotactic radiotherapy (hSRT) with daily oral administration of the hypoxic sensitizer AK-2123 (sanazole) for progressive brain metastases after previous radiotherapy. The patients received daily oral administration of 1.0 g/day sanazole up to 2 h before radiotherapy. Three partial and three stable responses were observed, with no sanazole-related toxicity, except for a case of mild nausea. Brain failure with subsequent death occurred in one patient. The other patients maintained good performance status until disease progression in other lesions. hSRT with a hypoxic radiation sensitizer appears to have the potential to enhance the efficacy of radiotherapy.
|
|---|---|
| Authors | Hideya Yamazaki, Satoaki Nakamura, Takuya Nishimura, Naohiro Kodani, Takuji Tsubokura, Takuya Kimoto, Hiroya Sihomi, Norihiro Aibe, Ken Yoshida, Masahiko Koizumi, Tsutomu Kagiya |
| Journal | Anticancer research (Anticancer Res) Vol. 33 Issue 4 Pg. 1773-6 (Apr 2013) ISSN: 1791-7530 [Electronic] Greece |
| PMID | 23564833 (Publication Type: Journal Article) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!