Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia.

To determine whether a high prevalence (55%) of Aβ deposition in a cohort of individuals remaining dementia-free into their 9th and 10th decades is associated with cognitive decline prior to imaging.
A total of 194 participants (mean age 85.5 years, range 82-95) who completed the Ginkgo Evaluation of Memory Study (GEMS) and remained dementia-free subsequently completed Pittsburgh compound B-PET imaging. We examined cross-sectional associations between Aβ status and performance on a broad neuropsychological test battery completed at GEMS entry 7-9 years prior to neuroimaging. We also longitudinally examined cognition over annual evaluations using linear mixed models.
At GEMS screening (2000-2002), participants who were Aβ-positive in 2009 had lower performance on the Stroop test (p < 0.01) and Raven's Progressive Matrices (p = 0.05), with trend level difference for Block Design (p = 0.07). Longitudinal analyses showed significant slope differences for immediate and delayed recall of the Rey-Osterrieth figure, semantic fluency, and Trail-Making Test parts A and B, indicating greater performance decline prior to neuroimaging for Aβ-positive relative to Aβ-negative participants (ps < 0.05).
Highly prevalent Aβ deposition in oldest-older adults is associated with cognitive decline in visual memory, semantic fluency, and psychomotor speed beginning 7-9 years prior to neuroimaging. Mean differences in nonmemory domains, primarily executive functions, between Aβ-status groups may be detectable 7-9 years before neuroimaging.
AuthorsBeth E Snitz, Lisa A Weissfeld, Oscar L Lopez, Lewis H Kuller, Judith Saxton, Dilrukshika M Singhabahu, William E Klunk, Chester A Mathis, Julie C Price, Diane G Ives, Ann D Cohen, Eric McDade, Steven T Dekosky
JournalNeurology (Neurology) Vol. 80 Issue 15 Pg. 1378-84 (Apr 9 2013) ISSN: 1526-632X [Electronic] United States
PMID23516317 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
Chemical References
  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • Amyloid beta-Peptides
  • Aniline Compounds
  • Plant Preparations
  • Thiazoles
  • Aged
  • Aged, 80 and over
  • Amyloid beta-Peptides (metabolism)
  • Aniline Compounds
  • Cognition Disorders (complications, drug therapy)
  • Cross-Sectional Studies
  • Dementia (etiology, prevention & control, radionuclide imaging)
  • Double-Blind Method
  • Female
  • Ginkgo biloba
  • Humans
  • Linear Models
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Neuropsychological Tests
  • Phytotherapy (methods)
  • Plant Preparations (therapeutic use)
  • Positron-Emission Tomography
  • Psychiatric Status Rating Scales
  • Retrospective Studies
  • Thiazoles

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