HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia.

AbstractOBJECTIVE:
To determine whether a high prevalence (55%) of Aβ deposition in a cohort of individuals remaining dementia-free into their 9th and 10th decades is associated with cognitive decline prior to imaging.
METHODS:
A total of 194 participants (mean age 85.5 years, range 82-95) who completed the Ginkgo Evaluation of Memory Study (GEMS) and remained dementia-free subsequently completed Pittsburgh compound B-PET imaging. We examined cross-sectional associations between Aβ status and performance on a broad neuropsychological test battery completed at GEMS entry 7-9 years prior to neuroimaging. We also longitudinally examined cognition over annual evaluations using linear mixed models.
RESULTS:
At GEMS screening (2000-2002), participants who were Aβ-positive in 2009 had lower performance on the Stroop test (p < 0.01) and Raven's Progressive Matrices (p = 0.05), with trend level difference for Block Design (p = 0.07). Longitudinal analyses showed significant slope differences for immediate and delayed recall of the Rey-Osterrieth figure, semantic fluency, and Trail-Making Test parts A and B, indicating greater performance decline prior to neuroimaging for Aβ-positive relative to Aβ-negative participants (ps < 0.05).
CONCLUSIONS:
Highly prevalent Aβ deposition in oldest-older adults is associated with cognitive decline in visual memory, semantic fluency, and psychomotor speed beginning 7-9 years prior to neuroimaging. Mean differences in nonmemory domains, primarily executive functions, between Aβ-status groups may be detectable 7-9 years before neuroimaging.
AuthorsBeth E Snitz, Lisa A Weissfeld, Oscar L Lopez, Lewis H Kuller, Judith Saxton, Dilrukshika M Singhabahu, William E Klunk, Chester A Mathis, Julie C Price, Diane G Ives, Ann D Cohen, Eric McDade, Steven T Dekosky
JournalNeurology (Neurology) Vol. 80 Issue 15 Pg. 1378-84 (Apr 9 2013) ISSN: 1526-632X [Electronic] United States
PMID23516317 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
Chemical References
  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • Amyloid beta-Peptides
  • Aniline Compounds
  • Plant Preparations
  • Thiazoles
Topics
  • Aged
  • Aged, 80 and over
  • Amyloid beta-Peptides (metabolism)
  • Aniline Compounds
  • Cognition Disorders (complications, drug therapy)
  • Cross-Sectional Studies
  • Dementia (etiology, prevention & control, radionuclide imaging)
  • Double-Blind Method
  • Female
  • Ginkgo biloba
  • Humans
  • Linear Models
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Neuropsychological Tests
  • Phytotherapy (methods)
  • Plant Preparations (therapeutic use)
  • Positron-Emission Tomography
  • Psychiatric Status Rating Scales
  • Retrospective Studies
  • Thiazoles

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: