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GABA predicts inhibition of frequency-specific oscillations in schizophrenia.

Abstract
This study is the first to show a relationship between in-vivo brain gamma-amino butyric acid (GABA) levels and auditory inhibitory electrophysiological measures in schizophrenia. Results revealed a strong association between GABA levels and gating of the theta-alpha and beta activities in schizophrenia.
AuthorsLaura M Rowland, Richard A E Edden, Kimberly Kontson, He Zhu, Peter B Barker, L Elliot Hong
JournalThe Journal of neuropsychiatry and clinical neurosciences (J Neuropsychiatry Clin Neurosci) Vol. 25 Issue 1 Pg. 83-7 ( 2013) ISSN: 1545-7222 [Electronic] United States
PMID23487198 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • gamma-Aminobutyric Acid
Topics
  • Acoustic Stimulation
  • Adult
  • Brain (metabolism, physiopathology)
  • Brain Mapping
  • Electroencephalography
  • Female
  • Humans
  • Inhibition, Psychological
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Schizophrenia (pathology)
  • Theta Rhythm (physiology)
  • gamma-Aminobutyric Acid (metabolism)

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