Exercise-related complications in sickle cell trait.

Abstract

This review presents the epidemiological data regarding the exercise-related complication in exercising sickle cell trait carriers, and focuses on the different potential mechanisms that could be involved in these adverse events, such as hemorheological alterations, inflammation, vascular adhesion of circulating blood cells, oxidative stress and impaired nitric oxide metabolism. We also discuss the effects of different modulating factors such as vascular function, environment (hot temperature), hydration status, physical fitness, exercise intensity and genetic factors.

• Authors: Julien Tripette, Marie-Dominique Hardy-Dessources, Marc Romana, Olivier Hue, Mor Diaw, Abdoulaye Samb, Saliou Diop, Philippe Connes
• Journal: Clinical hemorheology and microcirculation (Clin Hemorheol Microcirc) Vol. 55 Issue 1 Pg. 29-37 ( 2013) ISSN: 1875-8622 [Electronic] Netherlands
• PMID: 23478224 (Publication Type: Journal Article, Review)

Topics

• Exercise (physiology)
• Hemorheology (physiology)
• Humans
• Sickle Cell Trait (blood, complications, physiopathology)