Endothelial function and weight loss: comparison of low-carbohydrate and low-fat diets.

Abstract

OBJECTIVE:

The effect of weight loss on obesity-associated endothelial dysfunction is not clear because of conflicting data, demonstrating both improvement and no change in endothelial function after weight loss in obese subjects. A 2-year prospective study (n = 121) was conducted to examine: (1) the effect of obesity and weight loss (either a low-carbohydrate or and low-fat diet) on flow mediated vasodilatation (FMD), a measure of endothelial function.

DESIGN AND METHODS:

Participants reduced body weight by 7.1% ± 4.4%, 8.7% ± 6.8%, 7.1% ± 7.8%, and 4.1% ± 7.7% at 3, 6, 12, and 24 months, respectively with no significant differences between the low-fat and low-carbohydrate groups.

RESULTS:

Endothelial function was inversely correlated with waist circumference, triglyceride level, and directly correlated with leptin in obese persons prior to weight loss. These weight losses did not confer any improvements in FMD. There were no differences between the low-fat and low-carbohydrate diets in FMD at any time point. At 6 months (r = 0.26, P = 0.04) and 1 year (r =0.28, P = 0.03), there were positive correlations between change in FMD and change in leptin but not at 2 years.

CONCLUSION:

There was no significant improvement in endothelial function after 7.1% ± 7.8% weight loss at 1 year and 4.1% ± 7.7% at 2 years, achieved by either a low carbohydrate or a low fat diet.

• Authors: Emile R Mohler 3rd, Alexandra A Sibley, Richard Stein, Victor Davila-Roman, Holly Wyatt, Karen Badellino, Daniel J Rader, Samuel Klein, Gary D Foster
• Journal: Obesity (Silver Spring, Md.) (Obesity (Silver Spring)) Vol. 21 Issue 3 Pg. 504-9 (Mar 2013) ISSN: 1930-739X [Electronic] United States
• PMID: 23404949 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 The Obesity Society.

Chemical References

• Leptin
• Triglycerides

Topics

• Adult
• Blood Pressure
• Body Mass Index
• Body Weight
• Brachial Artery (metabolism)
• Diet, Carbohydrate-Restricted
• Diet, Fat-Restricted
• Endothelium (metabolism)
• Female
• Humans
• Image Processing, Computer-Assisted
• Leptin (blood)
• Male
• Middle Aged
• Obesity (diet therapy)
• Prospective Studies
• Risk Factors
• Triglycerides (blood)
• Vasodilation
• Waist Circumference
• Weight Loss