Subepithelial connective tissue graft with growth factor for the treatment of maxillary gingival recession defects.

Abstract	Gingival recession is a challenging defect for clinicians to treat effectively. A number of recent systematic reviews have identified the connective tissue graft (CTG) in combination with coronally advanced flaps (CAFs) as the most consistently effective treatment for Miller Class I and II defects across all outcome measures. Recent advances in recombinant growth factor technology may provide opportunities for improved outcomes in conjunction with CAF + CTG procedures. In this prospective consecutive case series, recombinant human platelet-derived growth factor BB (rhPDGF-BB) was combined with CTGs for the treatment of Miller Class I or II gingival recession defects. Improved outcomes were seen for keratinized tissue gains and percent root coverage at 6 months postsurgery when compared to historic norms. All other outcome parameters appeared equivalent between the two treatment approaches. The addition of rhPDGF-BB appeared to improve early wound healing as well.
Authors	Robert P Rubins, Paul N Tolmie, Kenneth T Corsig, Eric N Kerr, David M Kim
Journal	The International journal of periodontics & restorative dentistry (Int J Periodontics Restorative Dent) 2013 Jan-Feb Vol. 33 Issue 1 Pg. 43-50 ISSN: 1945-3388 [Electronic] United States
PMID	23342346 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Angiogenesis Inducing Agents Proto-Oncogene Proteins c-sis Recombinant Proteins Becaplermin
Topics	Adult Angiogenesis Inducing Agents (therapeutic use) Becaplermin Combined Modality Therapy Connective Tissue (transplantation) Dental Plaque Index Female Follow-Up Studies Gingiva (drug effects, pathology, transplantation) Gingival Recession (drug therapy, surgery) Humans Male Middle Aged Periodontal Attachment Loss (classification) Periodontal Index Periodontal Pocket (classification) Prospective Studies Proto-Oncogene Proteins c-sis (therapeutic use) Recombinant Proteins Surgical Flaps (transplantation) Tooth Root (surgery) Treatment Outcome Wound Healing (drug effects)

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