Abstract |
Although a decrease in acquired immunodeficiency syndrome ( AIDS)-related mortality has been documented in highly active antiretroviral therapy ( HAART) era, there are no published data comparing specific causes of death between pre- HAART and HAART era in Korea. Mortality and cause of death were analyzed in three treatment periods; pre- HAART (1990-1997), early- HAART (1998-2001), and late- HAART period (2002-2011). The patients were retrospectively classified according to the treatment period in which they were recruited. Although mortality rate per 100 person-year declined from 8.7 in pre- HAART to 4.9 in late- HAART period, the proportion of deaths within 3 months of initial visit to study hospital significantly increased from 15.9% in pre- HAART to 55.1% in late- HAART period (P < 0.001). Overall, 59% of deaths were attributable to AIDS-related conditions, and Pneumocystis pneumonia (PCP) was the most common cause of death (20.3%). The proportion of PCP as cause of death significantly increased from 8.7% in pre- HAART to 31.8% in late- HAART period (P < 0.001). Despite of significant improvement of survival, there was still a high risk of early death in patients presenting in HAART era, mainly due to late human immunodeficiency virus (HIV) diagnosis and late presentation to care.
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Authors | Sun Hee Lee, Kye-Hyung Kim, Seung Geun Lee, Dong Hwan Chen, Dong Sik Jung, Chi Sook Moon, Ji Young Park, Joo Seop Chung, Ihm Soo Kwak, Goon Jae Cho |
Journal | Journal of Korean medical science
(J Korean Med Sci)
Vol. 28
Issue 1
Pg. 67-73
(Jan 2013)
ISSN: 1598-6357 [Electronic] Korea (South) |
PMID | 23341714
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Acquired Immunodeficiency Syndrome
(mortality)
- Adult
- Antiretroviral Therapy, Highly Active
- Cause of Death
(trends)
- Female
- HIV Infections
(drug therapy, mortality)
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Pneumonia, Pneumocystis
(mortality)
- Republic of Korea
- Retrospective Studies
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