Abstract | BACKGROUND: METHODS: Pulmonary function tests, St. George's Respiratory Questionnaire (SGRQ) and MDCT imaging studies were performed at the beginning and after budesonide/ formoterol combination treatment for 12 weeks in 14 patients with COPD. RESULTS: The median age was 73.5 years and the mean forced expiratory volume in 1 s (FEV1) as a percentage of the predicted value was 57.2 ± 18.3%. The luminal area in the fifth generation bronchi and the emphysema volume/CT-derived total lung volume were significantly correlated with FEV1 at baseline (r = 0.682, p < 0.02 and r = -0.868, p < 0.001, respectively). The average luminal area and wall area percentage in the third, fourth and fifth generations were correlated with the SGRQ total score. Budesonide/ formoterol induced insignificant pulmonary function changes and significant symptoms improvement. CT images showed an increased inner luminal area and decreased wall area after budesonide/ formoterol treatment. Average luminal area was significantly increased from 24.3 ± 9.7 to 26.0 ± 9.9 mm(2) in the third generation, 13.0 ± 6.5 to 14.7 ± 7.3 mm(2) in the fourth generation, 8.0 ± 4.8 to 9.4 ± 4.9 mm(2) in the fifth generation and 5.6 ± 2.7 to 6.7 ± 3.6 mm(2) in the sixth generation (p < 0.01). The average increase of the third generation luminal area was correlated with the FEV1 increase (r = 0.632, p < 0.03). The wall area percentage significantly decreased from 51.5 ± 9.2 to 49.1 ± 9.7 in the third generation, 56.1 ± 9.7 to 53.0 ± 11.1 in the fourth generation, and 62.3 ± 9.9 to 57.6 ± 9.8 in the fifth generation (p < 0.05). Emphysema volume/CT-derived total lung volume was unchanged with treatment. CONCLUSION:
|
Authors | Hideki Yasui, Naoki Inui, Kazuki Furuhashi, Yutaro Nakamura, Tomohiro Uto, Jun Sato, Kazumasa Yasuda, Yasuo Takehara, Takafumi Suda, Kingo Chida |
Journal | Pulmonary pharmacology & therapeutics
(Pulm Pharmacol Ther)
Vol. 26
Issue 3
Pg. 336-41
(Jun 2013)
ISSN: 1522-9629 [Electronic] England |
PMID | 23340058
(Publication Type: Journal Article)
|
Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Bronchodilator Agents
- Drug Combinations
- Ethanolamines
- Scopolamine Derivatives
- Budesonide
- Formoterol Fumarate
- Tiotropium Bromide
|
Topics |
- Aged
- Aged, 80 and over
- Bronchodilator Agents
(administration & dosage, pharmacology, therapeutic use)
- Budesonide
(administration & dosage, pharmacology, therapeutic use)
- Drug Combinations
- Ethanolamines
(administration & dosage, pharmacology, therapeutic use)
- Female
- Formoterol Fumarate
- Humans
- Lung
(diagnostic imaging, physiopathology)
- Male
- Middle Aged
- Multidetector Computed Tomography
- Pilot Projects
- Pulmonary Disease, Chronic Obstructive
(drug therapy, physiopathology)
- Respiratory Function Tests
- Scopolamine Derivatives
(administration & dosage, pharmacology, therapeutic use)
- Tiotropium Bromide
|