Two decades of occupational (meth)acrylate patch test results and focus on isobornyl acrylate.

Abstract

BACKGROUND:

Acrylates constitute an important cause of occupational contact dermatitis. Isobornyl acrylate sensitization has been reported in only 2 cases. We encountered an industrial process operator with occupational contact dermatitis caused by isobornyl acrylate.

OBJECTIVES:

(i) To investigate whether it is relevant to add isobornyl acrylate to the (meth)acrylate test series. (ii) To report patients with (meth)acrylate contact allergy at an occupational dermatology clinic.

PATIENTS/MATERIALS/METHODS:

Our patch test database was screened for positive reactions to (meth)acrylates between 1993 and 2012. A selected group of 14 patients was tested with an isobornyl acrylate dilution series: 0.3%, 0.1%, 0.033%, and 0.01%. Readings were performed on D2, D3, and D7.

RESULTS:

One hundred and fifty-one patients were tested with our (meth)acrylate series; 24 had positive reactions. Most positive reactions were to 2-hydroxypropyl acrylate, 2-hydroxyethyl acrylate, 2-hydroxypropyl methacrylate, and diethyleneglycol diacrylate. Hypothetical screening with 2-hydroxypropyl acrylate, ethyleneglycol dimethacrylate, ethoxylated bisphenol A glycol dimethacrylate and trimethylolpropane triacrylate identified 91.7% of the 24 patients. No positive reactions were observed in 14 acrylate-positive patients tested with the isobornyl acrylate dilution series. The 0.3% isobornyl acrylate concentration induced irritant reactions in 3 patients.

CONCLUSIONS:

We report a rare case of allergic contact dermatitis caused by isobornyl acrylate. However, this study provides insufficient support for isobornyl acrylate to be added to a (meth)acrylate series.

• Authors: Wietske A Christoffers, Pieter-Jan Coenraads, Marie-Louise A Schuttelaar
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 69 Issue 2 Pg. 86-92 (Aug 2013) ISSN: 1600-0536 [Electronic] England
• PMID: 23336843 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Acrylates
• Allergens
• Camphanes
• Methacrylates
• isobornyl acrylate

Topics

• Acrylates (adverse effects)
• Adult
• Aged
• Allergens (adverse effects)
• Camphanes (adverse effects)
• Dermatitis, Allergic Contact (etiology)
• Dermatitis, Occupational (etiology)
• Female
• Hand Dermatoses (etiology)
• Humans
• Male
• Methacrylates (adverse effects)
• Middle Aged