Risk of life-threatening cardiac events among patients with long QT syndrome and multiple mutations.

Abstract

BACKGROUND:

Patients with long QT syndrome (LQTS) who harbor multiple mutations (i.e. ≥ 2 mutations in ≥ 1 LQTS-susceptibility gene) may experience increased risk for life-threatening cardiac events.

OBJECTIVES:

The present study was designed to compare the clinical course of LQTS patients with multiple mutations to those with a single mutation.

METHODS:

The risk for life-threatening cardiac events (comprising aborted cardiac arrest, implantable defibrillator shock, or sudden cardiac death) from birth through age 40 years, by the presence of multiple vs. single mutations, was assessed among 403 patients from the LQTS Registry.

RESULTS:

Patients with multiple mutations (n=57) exhibited a longer QTc at enrollment compared with those with a single mutation (mean ± SD: 506 ± 72 vs. 480 ± 56 msec, respectively; P=0.003) and had a higher rate of life threatening cardiac events during follow-up (23% vs. 11%, respectively; p=0.031). Consistently, multivariate analysis demonstrated that patients with multiple mutations had a 2.3-fold (P=0.015) increased risk for life threatening cardiac events as compared to patients with a single mutation. The presence of multiple mutations in a single LQTS gene was associated with a 3.2-fold increased risk for life threatening cardiac events (P=0.010) whereas the risk associated with multiple mutation status involving >1 LQTS gene was not significantly different from the risk associated with a single mutation (HR 1.7, P=0.26).

CONCLUSIONS:

LQTS patients with multiple mutations have a greater risk for life-threatening cardiac events as compared to patients with a single mutation.

• Authors: Jamie Mullally, Ilan Goldenberg, Arthur J Moss, Coeli M Lopes, Michael J Ackerman, Wojciech Zareba, Scott McNitt, Jennifer L Robinson, Jesaia Benhorin, Elizabeth S Kaufman, Jeffrey A Towbin, Alon Barsheshet
• Journal: Heart rhythm (Heart Rhythm) Vol. 10 Issue 3 Pg. 378-82 (Mar 2013) ISSN: 1556-3871 [Electronic] United States
• PMID: 23174487 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2013 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Topics

• Adult
• Death, Sudden, Cardiac (epidemiology, etiology)
• Electrocardiography
• Female
• Follow-Up Studies
• Genetic Predisposition to Disease
• Genotype
• Global Health
• Humans
• Incidence
• Long QT Syndrome (complications, genetics)
• Male
• Mutation
• Registries
• Risk Factors
• Survival Rate (trends)
• Young Adult