Oral mucositis: etiology, and clinical and pharmaceutical management.

Abstract

Oral mucosal damage is one of the common and worst side effects of radiotherapy and chemotherapy treatment for cancer. With prevalence between 10% and 100%, depending on the cytotoxic and/or radiotherapy regimen and patient-associated variables, this morbid condition represents a significant problem in oncology. This article addresses oral mucositis and discusses its prevalence, risk factors, clinical and economical impacts, etiology, and clinical management in view of the most recent evidence. Despite clear progress and the development of clinical guidelines on this topic, what we currently have to offer to patients to manage mucositis and oropharyngeal pain is still inadequate. This article offers two compounded preparations supported by evidence-based data to treat oral mucositis. Expansion of the knowledge of the pathogenesis of mucositis as well as a better insight into individual risk factors will provide opportunities to improve management strategies.

• Authors: Eyal Zur
• Journal: International journal of pharmaceutical compounding (Int J Pharm Compd) 2012 Jan-Feb Vol. 16 Issue 1 Pg. 22-33 ISSN: 1092-4221 [Print] United States
• PMID: 23050308 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents

Topics

• Antineoplastic Agents (adverse effects)
• Drug Compounding
• Humans
• Practice Guidelines as Topic
• Radiotherapy (adverse effects)
• Risk Factors
• Stomatitis (drug therapy, economics, etiology)
• Whole-Body Irradiation (adverse effects)