Abstract | OBJECTIVES: Microalbuminuria is closely associated with an increased risk of renal and cardiovascular adverse outcomes. The present study tested the hypothesis that titration of telmisartan reduces urinary excretion of albumin more than does addition of amlodipine in patients treated with a standard dose of telmisartan combined with a low-dose diuretic for the same degree of blood pressure (BP) reduction. METHODS: RESULTS: Although BP was reduced to a similar extent by the two regimens, patients receiving the increased dose ARB showed a higher reduction in urinary albumin (-37.4 ± 16.9%) than those on the triple combination regimen (-8.9 ± 23.7%; P < 0.0001). The reduction in urinary albumin was correlated with the drop in BP in the latter group, but not in the increased dose ARB group. CONCLUSION:
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Authors | Masayoshi Kojima, Masuo Ohashi, Yasuaki Dohi, Genjiro Kimura |
Journal | Journal of hypertension
(J Hypertens)
Vol. 31
Issue 1
Pg. 186-91
(Jan 2013)
ISSN: 1473-5598 [Electronic] England |
PMID | 23047595
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Benzimidazoles
- Benzoates
- Diuretics
- Amlodipine
- Telmisartan
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Topics |
- Adult
- Aged
- Albuminuria
(drug therapy)
- Amlodipine
(administration & dosage)
- Angiotensin II Type 1 Receptor Blockers
(administration & dosage)
- Benzimidazoles
(administration & dosage)
- Benzoates
(administration & dosage)
- Blood Pressure
(drug effects)
- Diabetes Mellitus, Type 2
(complications, drug therapy)
- Diuretics
(administration & dosage)
- Female
- Humans
- Hypertension
(complications, drug therapy)
- Male
- Middle Aged
- Prospective Studies
- Telmisartan
- Treatment Outcome
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