Abstract | BACKGROUND: METHODS: A case series with retrospective review of 19 patients with AFRS and 21 patients with CRSwNP was performed at a tertiary referral center. The diagnosis of AFRS required the presence of defined criteria described by Bent and Kuhn. Bacterial cultures and fungal cultures were analyzed for each group. RESULTS: S. aureus was significantly more prevalent in the AFRS group compared with the non-AFRS group (63.2% vs 24.1%, p = 0.005). CONCLUSION: S. aureus has been implicated as a disease modifier in CRSwNP through superantigen-mediated mechanisms. This study demonstrates a higher prevalence of S. aureus in patients with AFRS vs patients with other subsets of CRSwNP (non-AFRS). These results support a potential role for S. aureus in the pathogenesis of AFRS.
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Authors | David W Clark, Ashley Wenaas, Amber Luong, Martin J Citardi, Samer Fakhri |
Journal | International forum of allergy & rhinology
(Int Forum Allergy Rhinol)
Vol. 3
Issue 2
Pg. 89-93
(Feb 2013)
ISSN: 2042-6984 [Electronic] United States |
PMID | 23038642
(Publication Type: Journal Article)
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Copyright | © 2013 ARS-AAOA, LLC. |
Topics |
- Adult
- Chronic Disease
- Female
- Humans
- Male
- Middle Aged
- Nasal Polyps
(microbiology)
- Retrospective Studies
- Rhinitis
(epidemiology, microbiology)
- Sinusitis
(microbiology)
- Staphylococcal Infections
(epidemiology, microbiology)
- Staphylococcus aureus
(isolation & purification)
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