Acute liver failure following minocycline treatment - a case report and review of the literature.

Abstract

We present the case of a 23-year-old female patient with acute liver failure following intake of minocycline. This patient had severe hypereosinophilia and massively increased IgE levels. Experimental studies in this case revealed elevated IFN-γ-, as well as TNF-α-producing CD4+ and CD8+ T-cells after in vitro stimulation with minocycline, indicating a type I/IgE-mediated as well as type II/cytotoxic reaction in the pathogenesis of minocycline-induced liver failure. Although mild forms of liver involvement are well known side effects of minocycline, only 8 cases with acute liver failure have been reported, and we present a review of all cases.

• Authors: A Kuhn, C Weiler-Normann, C Schramm, S Kluge, M J Behne, A W Lohse, D Benten
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 50 Issue 8 Pg. 771-5 (Aug 2012) ISSN: 1439-7803 [Electronic] Germany
• PMID: 22895906 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Anti-Bacterial Agents
• Minocycline

Topics

• Anti-Bacterial Agents (adverse effects)
• Diagnosis, Differential
• Female
• Humans
• Liver Failure, Acute (chemically induced, diagnosis, prevention & control)
• Minocycline (adverse effects)
• Young Adult