Abstract | BACKGROUND: METHODS: This is a cross-sectional cohort study assessing prediabetes with proteinuria in a large Japanese population. Using a nationwide health checkup database of 228 778 Japanese aged ≥20 years (median 66 years; 39.3% were men; none had pre-existing cardiovascular disease), we examined the association between prediabetes and proteinuria (≥1+ on dipstick) separately in prediabetes subjects diagnosed with the new hemoglobin A1c (HbA1c) criterion only (PD-A1c), the impaired fasting plasma glucose only (PD-IFG) and fulfilling both criteria (PD-Both). RESULTS: According to the American Diabetes Association's (ADA's) criterion of 5.7-6.4% HbA1c and/or 100-125 mg/dL fasting plasma glucose, 43.8% of the subjects were judged as having prediabetes. Prediabetes subjects were divided into subclasses of PD-A1c (53.7%), PD-IFG (21.7%) and PD-Both (24.5%), respectively. Therefore, 21.7% of prediabetes subjects were missed using the new HbA1c criterion only. Compared with subjects with normal glucose tolerance (as a reference), the odds ratio (OR) [95% confidence interval (95% CI)] for the increased risk of proteinuria (≥1+) in diabetes itself was 2.191 (2.081-2.307) and in whole prediabetes was 1.093 (1.046-1.142); when prediabetes was subdivided, the OR for proteinuria in PD-IFG was 1.217 (1.140-1.300) and that in PD-Both was 1.249 (1.174-1.329), but that in PD-A1c was not significant, even after adjustment for significant covariates, such as age, sex, body mass index, systolic blood pressure, antihypertensive medication, eGFR, lifestyle and lipid profile. CONCLUSIONS:
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Authors | Yuji Sato, Yuichiro Yano, Shouichi Fujimoto, Tsuneo Konta, Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Hideaki Yoshida, Koichi Asahi, Issei Kurahashi, Yasuo Ohashi, Tsuyoshi Watanabe |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 27
Issue 10
Pg. 3862-8
(Oct 2012)
ISSN: 1460-2385 [Electronic] England |
PMID | 22859789
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- hemoglobin A1c protein, human
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Topics |
- Aged
- Blood Glucose
(metabolism)
- Cohort Studies
- Cross-Sectional Studies
- Early Diagnosis
- Fasting
- Female
- Glycated Hemoglobin
(metabolism)
- Humans
- Japan
(epidemiology)
- Male
- Middle Aged
- Prediabetic State
(blood, diagnosis, epidemiology)
- Predictive Value of Tests
- Proteinuria
(blood, diagnosis, epidemiology)
- Risk Factors
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