Abstract | BACKGROUND: METHODS: This case series included 20 transplant-naïve patients who were enrolled in two phase I multicenter studies. Patients received brentuximab vedotin intravenously every 3 weeks or every week for 3 out of 4 weeks. RESULTS: The majority of patients were transplant-naïve because of chemorefractory disease. Median age was 31.5 years (range, 12-87 years). Treatment-emergent adverse events in >20% of patients were peripheral neuropathy, fatigue, nausea, pyrexia, diarrhea, weight decreased, anemia, back pain, decreased appetite, night sweats, and vomiting; most events were grade 1 or 2. Six patients obtained objective responses: two complete remissions and four partial remissions. Median duration of response was not met; censored durations ranged from >6.8 to >13.8 months. Three of six responders subsequently received ASCT. CONCLUSION:
Brentuximab vedotin was associated with manageable adverse events in transplant-naïve patients with relapsed or refractory HL. The objective responses observed demonstrate that antitumor activity is not limited to patients who received brentuximab vedotin after ASCT. The promising activity observed in this population warrants further study.
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Authors | Andres Forero-Torres, Michelle Fanale, Ranjana Advani, Nancy L Bartlett, Joseph D Rosenblatt, Dana A Kennedy, Anas Younes |
Journal | The oncologist
(Oncologist)
Vol. 17
Issue 8
Pg. 1073-80
( 2012)
ISSN: 1549-490X [Electronic] England |
PMID | 22855426
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoconjugates
- Ki-1 Antigen
- Oligopeptides
- Brentuximab Vedotin
- monomethyl auristatin E
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Brentuximab Vedotin
- Child
- Clinical Trials, Phase I as Topic
- Female
- Hodgkin Disease
(drug therapy, pathology)
- Humans
- Immunoconjugates
(adverse effects, therapeutic use)
- Ki-1 Antigen
(metabolism)
- Male
- Middle Aged
- Neoplasm Staging
- Oligopeptides
(therapeutic use)
- Stem Cell Transplantation
- Transplantation, Autologous
- Treatment Outcome
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