Abstract |
Interdigitating dendritic cell sarcoma (IDCS) is a very rare and aggressive neoplasm that arises from antigen presenting cells. IDCS usually involves lymph nodes; however, extra-nodal involvement has also been reported. Because a consistent standard therapy for IDCS has not been established to date, we report a case of the successful treatment of disseminated IDCS using ABVD chemotherapy ( doxorubicin, bleomycin, vinblastine, and dacarbazine). A 64-year-old man was diagnosed with IDCS on the basis of immunohistochemical findings of a biopsy specimen of the inferior nasal concha. Immunohistochemical staining showed a positive reaction for CD68, leukocyte common antigen, and S-100 protein, but a negative reaction for CD34, CD1a, and CD21. Imaging studies showed cervical and axillary lymphadenopathies, subcutaneous nodules, and a soft tissue lesion in the nasal cavity. Treatment with the ABVD regimen resulted in complete remission after 8 cycles of chemotherapy.
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Authors | Suk-Young Lee, Se Ryeon Lee, Won Jin Chang, Hye Sook Kim, Byung Soo Kim, In Sun Kim |
Journal | The Korean journal of hematology
(Korean J Hematol)
Vol. 47
Issue 2
Pg. 150-3
(Jun 2012)
ISSN: 2092-9129 [Electronic] Korea (South) |
PMID | 22783364
(Publication Type: Case Reports)
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