Abstract | BACKGROUND AND AIMS: Hepatitis C virus (HCV) infection is reported to be associated with or to cause type 2 diabetes mellitus (T2DM). Our study aimed to elucidate the role of triglyceride (TG) and cholesterol (CHOL) levels in the association between anti-HCV seropositivity and T2DM in an HCV-endemic area. METHODS: We analyzed a computerized dataset of 56 338 residents from a community-based comprehensive screening program in Tainan County in southern Taiwan. Fasting glucose, anti-HCV status, hepatitis B surface antigen ( HBsAg) status, platelet counts, TG levels, CHOL levels, age, gender, and body mass index were included in the analyses. Multivariate logistic analysis was used to identify factors independently associated with T2DM. RESULTS: Older age, being overweight, thrombocytopenia, hypertriglyceridemia, hypercholesterolemia, anti-HCV seropositivity, and HBsAg seronegativity were common factors independently associated with diabetes. Among all models of multiple logistic regression analysis used for identifying factors independently associated with T2DM, anti-HCV seropositivity was only identified in the models that included either hypertriglyceridemia or hypercholesterolemia. When subjects were divided into hyperlipidemia (CHOL, > 200 or TG, > 150 mg/dL; n = 33 393) or non- hyperlipidemia subgroups (CHOL, < 200 and TG, < 150 mg/dL; n = 22 945), anti-HCV seropositivity was identified as an independent factor only in the non- hyperlipidemia subgroup. The odds ratio was 1.35, with a 95% confidence interval of 1.17-1.55. CONCLUSIONS: This study demonstrates that the lipid level is associated with the relationship between T2DM and anti-HCV seropositivity in non-hyperlipidemic individuals. However, the relationship between HCV and T2DM did not exist when the lipid level was not included in the analysis.
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Authors | Ju-Ling Liu, Jing-Yi Chen, Chao-Tung Chen, Jing-Houng Wang, Chih-Yun Lin, Pao-Fei Chen, Chao-Hung Hung, Kwong-Ming Kee, Chuan-Mo Lee, Lin-San Tsai, Shu-Chuan Chen, Sheng-Che Lin, Sheng-Nan Lu |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 27
Issue 11
Pg. 1688-94
(Nov 2012)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 22742891
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. |
Chemical References |
- Hepatitis C Antibodies
- Triglycerides
- Cholesterol
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Topics |
- Aged
- Cholesterol
(blood)
- Confidence Intervals
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(blood, complications, epidemiology)
- Female
- Health Surveys
- Hepacivirus
(immunology)
- Hepatitis C
(blood, complications, epidemiology)
- Hepatitis C Antibodies
(blood)
- Humans
- Hypercholesterolemia
(complications, epidemiology)
- Hypertriglyceridemia
(complications, epidemiology)
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Odds Ratio
- Prevalence
- Taiwan
(epidemiology)
- Triglycerides
(blood)
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