Edible Myrciaria vexator fruits: bioactive phenolics for potential COPD therapy.

Abstract

The edible fruits of Myrciaria vexator McVaugh (Myrtaceae), from northern South America, are eaten in certain locales, either fresh or processed into jellies and drinks. Activity-guided fractionation of M. vexator resulted in identification of ellagic acid (1), cyanidin-3-O-glucoside (2), delphinidin-3-O-glucoside (3), 2-O-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxyphenylacetic acid (4), and jaboticabin (5), and latter two compounds are being reported for the first time in this species. Ellagic acid was further examined, and found to inhibit cigarette smoke extract induced MMP-1 expression in vitro, and may be of significance in the treatment of chronic obstructive pulmonary (COPD). Other compounds identified for the first time from M. vexator include cyanidin-3-O-galactoside (6), cyanidin-3-O-arabinoside (7), cyanidin-3-O-rutionoside (8), petunidin (9), peonidin-3-O-galactoside (10) malvidin (11), hyperoside (12), querecetin-3-O-glucoside (13), and guajaverin (14), methyl protocatechuate (15), and protocatechuic acid (16).

• Authors: Keyvan Dastmalchi, Gema Flores, Shi-Biao Wu, Chunhui Ma, Abdoulaye J Dabo, Kathleen Whalen, Kurt A Reynertson, Robert F Foronjy, Jeanine M D Armiento, Edward J Kennelly
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 20 Issue 14 Pg. 4549-55 (Jul 15 2012) ISSN: 1464-3391 [Electronic] England
• PMID: 22739086 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2012. Published by Elsevier Ltd.

Chemical References

• Free Radical Scavengers
• Phenols
• Ellagic Acid
• Matrix Metalloproteinase 1

Topics

• Cells, Cultured
• Chromatography, High Pressure Liquid
• Ellagic Acid (chemistry, pharmacology, therapeutic use)
• Epithelial Cells (drug effects, metabolism)
• Free Radical Scavengers (chemistry, pharmacology, therapeutic use)
• Fruit (chemistry)
• Humans
• Mass Spectrometry
• Matrix Metalloproteinase 1 (metabolism)
• Myrtaceae (chemistry)
• Phenols (chemistry, pharmacology, therapeutic use)
• Pulmonary Disease, Chronic Obstructive (drug therapy)