Acupuncture regulates the glucose metabolism in cerebral functional regions in chronic stage ischemic stroke patients--a PET-CT cerebral functional imaging study.

Abstract

BACKGROUND:

Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke patients were randomly divided into 5 groups: the Waiguan (TE5) needling group, the TE5 sham needling group, the sham point needling group, the sham point sham needling group and the non-needling group. Cerebral functional images of all patients were then acquired using PET-CT scans and processed by SPM2 software.

RESULTS:

Compared with the non-needling group, sham needling at TE5 and needling/sham needling at the sham point did not activate cerebral areas. However, needling at TE5 resulted in the activation of Brodmann Area (BA) 30. Needling/sham needling at TE5 and needling at the sham point did not deactivate any cerebral areas, whereas sham needling at the sham point led to deactivation in BA6. Compared with sham needling at TE5, needling at TE5 activated BA13, 19 and 47 and did not deactivate any areas. Compared with needling at the sham point, needling at TE5 had no associated activation but a deactivating effect on BA9.

CONCLUSION:

Needling at TE5 had a regulating effect on cerebral functional areas shown by PET-CT, and this may relate to its impact on the recovery of post-stroke patients.

• Authors: Yong Huang, Chunzhi Tang, Shuxia Wang, Yangjia Lu, Wei Shen, Junjun Yang, Junqi Chen, Renyong Lin, Shaoyang Cui, Huiling Xiao, Shanshan Qu, Xinsheng Lai, Baoci Shan
• Journal: BMC neuroscience (BMC Neurosci) Vol. 13 Pg. 75 (Jun 27 2012) ISSN: 1471-2202 [Electronic] England
• PMID: 22738270 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Fluorodeoxyglucose F18
• Glucose

Topics

• Acupuncture Points
• Acupuncture Therapy (methods)
• Brain Mapping
• Cerebral Cortex (diagnostic imaging)
• Female
• Fluorodeoxyglucose F18
• Glucose (metabolism)
• Humans
• Linear Models
• Male
• Middle Aged
• Positron-Emission Tomography
• Single-Blind Method
• Stroke (diagnostic imaging, therapy)
• Tomography, X-Ray Computed