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The aryl hydrocarbon receptor in tumor immunity.

Abstract
The aryl hydrocarbon receptor (AHR) binds environmental toxins and mediates immune regulation. The tryptophan metabolite kynurenine has now been identified as an endogenous ligand of the human AHR constitutively produced by gliomas and other types of cancer via tryptophan-2,3-dioxygenase (TDO), thereby suppressing antitumor immune responses via the AHR. Thus, this pathway represents an important novel target for cancer immunotherapy.
AuthorsMichael Platten, Ulrike Litzenburger, Wolfgang Wick
JournalOncoimmunology (Oncoimmunology) Vol. 1 Issue 3 Pg. 396-397 (May 01 2012) ISSN: 2162-4011 [Print] United States
PMID22737628 (Publication Type: Journal Article)

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