Angiographically-assessed coronary artery disease associates with HDL particle size in women.

Abstract

UNLABELLED:

It has been suggested that a reduced HDL particle size could be another feature of the atherogenic dyslipidemia found among viscerally obese subjects.

OBJECTIVE:

To investigate, in women, the relationship between HDL particle size and coronary artery disease (CAD).

METHODS:

Average HDL particle size was measured in a sample of 239 women on whom CAD was assessed by angiography.

RESULTS:

Overall, women who had CAD were characterized by a deteriorated fasting metabolic risk profile, which was accompanied by smaller HDL particles compared to women without CAD (80.4 ± 2.2 Å vs. 81.5 ± 2.7 Å, p < 0.01). In addition, a reduced HDL particle size was a significant correlate of several features of the atherogenic metabolic profile of abdominal obesity such as increased triglyceride and apolipoprotein B concentrations, decreased HDL cholesterol levels, an elevated cholesterol/HDL cholesterol ratio and hyperinsulinemia and was also associated with an increased waist circumference (0.13≤|r|≤0.21, p < 0.05). Odds ratio of being affected by CAD was increased by 2.5-fold (95% CI: 1.4-4.5; p < 0.01) among women with smaller HDL particles compared to women with larger HDL particles. Finally, women characterized by the presence of the NCEP-ATP III clinical criteria or by hypertriglyceridemic waist were characterized by smaller HDL particles compared to women without these clinical phenotypes (p < 0.05).

CONCLUSION:

HDL particle size appears to be another relevant feature of a dysmetabolic state which is related to CAD risk in women.

• Authors: Patricia Blackburn, Isabelle Lemieux, Benoît Lamarche, Jean Bergeron, Patrice Perron, Gérald Tremblay, Daniel Gaudet, Jean-Pierre Després
• Journal: Atherosclerosis (Atherosclerosis) Vol. 223 Issue 2 Pg. 359-64 (Aug 2012) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 22695528 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Biomarkers
• Lipoproteins, HDL

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Chi-Square Distribution
• Coronary Angiography
• Coronary Artery Disease (diagnostic imaging, epidemiology)
• Cross-Sectional Studies
• Electrophoresis
• Female
• Humans
• Hypertriglyceridemia (blood, diagnosis, epidemiology)
• Lipoproteins, HDL (blood)
• Logistic Models
• Metabolic Syndrome (diagnosis, epidemiology)
• Middle Aged
• Obesity, Abdominal (diagnosis, epidemiology)
• Odds Ratio
• Particle Size
• Phenotype
• Predictive Value of Tests
• Quebec (epidemiology)
• Risk Assessment
• Risk Factors
• Waist Circumference