Non-small cell bronchial carcinoma metastasizing into a prolactin-producing pituitary adenoma.

Abstract

This study presents the case of a 66-year-old man with a non-small cell bronchial carcinoma that metastasized into a prolactin (PRL)-producing pituitary adenoma. The pituitary adenoma cells were immunoreactive for PRL and vascular endothelial growth factor (VEGF). It is hypothesized that VEGF and PRL played a role in the development of metastasis within the adenoma.

• Authors: Fabio Rotondo, Kalman Kovacs, R Loch Macdonald, Gerald J Prud'homme, Eleanor Latta, David Munoz
• Journal: International journal of surgical pathology (Int J Surg Pathol) Vol. 21 Issue 1 Pg. 68-71 (Feb 2013) ISSN: 1940-2465 [Electronic] United States
• PMID: 22689615 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Prolactin

Topics

• Aged
• Biomarkers, Tumor (metabolism)
• Bronchial Neoplasms (metabolism, pathology)
• Carcinoma, Non-Small-Cell Lung (metabolism, secondary)
• Fatal Outcome
• Humans
• Male
• Pituitary Neoplasms (metabolism, secondary)
• Prolactin (metabolism)
• Prolactinoma (metabolism, pathology)
• Vascular Endothelial Growth Factor A (metabolism)