Abstract | BACKGROUND: Chronic inflammation may play an etiologic role in ovarian and endometrial cancer, and it is hypothesized that nonsteroidal anti-inflammatory drugs ( NSAID) decrease the risk of developing these malignancies. No prospective study with a large multiethnic population has explored this hypothesis. METHODS: We investigated whether NSAID use was associated with risks of ovarian and endometrial cancer in the Multiethnic Cohort Study. Medication use of at least twice a week for ≥1 month was assessed at baseline. Multivariable relative risks (RR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. RESULTS: During 13.3 years of follow-up, 275 ovarian and 620 endometrial incident cases were identified among approximately 64,000 women included in this analysis (16.5% African Americans, 30.8% Japanese, 7.7% Native Hawaiians, 18.9%, Latinas, and 26.0% whites). The RR (95% CI) for ovarian cancer associated with aspirin, non- aspirin NSAIDs, and acetaminophen were 0.87 (0.68-1.14), 0.97 (0.74-1.26), and 0.86 (0.67-1.12), respectively. The RR (95% CI) for endometrial cancer associated with aspirin, non- aspirin NSAIDs, and acetaminophen were 0.93 (0.79-1.10), 0.88 (0.74-1.05), and 0.96 (0.81-1.13), respectively. No heterogeneity across ethnic groups (P ≥ 0.29) or dose-response relation with increased duration of use (P(trend) ≥ 0.16) was observed. The results did not differ by tumor histology. CONCLUSIONS: We found no compelling evidence to support an association between the use of NSAIDs and risk of ovarian and endometrial cancers in a multiethnic population. IMPACT:
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Authors | Veronica Wendy Setiawan, Rayna K Matsuno, Galina Lurie, Lynne R Wilkens, Michael E Carney, Brian E Henderson, Laurence N Kolonel, Marc T Goodman |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 21
Issue 9
Pg. 1441-9
(Sep 2012)
ISSN: 1538-7755 [Electronic] United States |
PMID | 22665579
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | ©2012 AACR |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
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Topics |
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Cohort Studies
- Endometrial Neoplasms
(ethnology, prevention & control)
- Female
- Humans
- Middle Aged
- Ovarian Neoplasms
(ethnology, prevention & control)
- Prospective Studies
- Risk
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