Abstract | BACKGROUND: We evaluated the effect of hypertension on hemodynamic responses and serum nitrite concentrations in normotensive (NT) and deoxycorticosteron acetate ( DOCA)- Salt hypertensive (HT) rats. METHODS: RESULTS: Changes in time-averaged MAP after hemorrhage were significantly greater in HT group than NT. After resuscitation, the HT rats failed to restore MAP to baseline level. Serum nitrite level in both groups was significantly increased during shock period. Survival rate of HT animals was lower than NT group, although it was not statistically significant. CONCLUSIONS: Marked reduction of MAP and less improvement after resuscitation suggested the less adaptation of cardiovascular system in HT animals which may interfere with management of these subjects during uncontrolled hemorrhagic shock.
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Authors | Majid Khazaei, Babak Barmaki, Ali Nasimi |
Journal | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
(Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub)
Vol. 156
Issue 3
Pg. 224-8
(Sep 2012)
ISSN: 1804-7521 [Electronic] Czech Republic |
PMID | 22660216
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Arterial Pressure
- Heart Rate
- Hypertension
(complications)
- Male
- Nitrites
(blood)
- Rats
- Rats, Wistar
- Resuscitation
- Shock, Hemorrhagic
(blood, complications, physiopathology)
- Sodium Chloride
(pharmacology)
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