Abstract | OBJECTIVE: METHODS: From January 2007 to October 2010, 67 patients with gastrointestinal cancer complicated with diabetes mellitus were admitted to the Liaocheng People's Hospital of Shandong Province and were randomized into the treatment group(n=33, enteral nutrition with probiotics, glutamine, and fish oil) and the routine group(n=34, regular enteral nutrition). Fasting blood glucose(FBG), insulin(FINS), number of lymphocytes(including CD3(+)T cell, CD4(+)T cell, CD8(+)T cell, CD4(+)/CD8(+)) and natural killer (NK) cells of the two groups were detected on the day before surgery and postoperative day 3 and 7. Insulin resistance index (InHOMA-IR) was calculated by using the homeostasis model assessment(HOMA). The incidence of nosocomial infections and intestinal function recovery time, and length of hospital stay were collected. RESULTS: On postoperative day 7, FINS[(8.4±3.7) mU/L vs. (13.7±5.4) mU/L, P<0.05] and InHOMA-IR(1.11±0.23 vs. 1.68±0.39, P<0.05) were lower in the treatment group than that in the routine group. The number of CD4(+)[(45.2±5.4)% vs. (38.1±2.9)%, P<0.05], CD4/CD8 (2.05±0.27 vs. 1.58±0.16, P<0.05), and NK cells [(19.5±6.6)% vs. (15.4±5.6)%, P<0.05] were higher in the treatment group. There were no significant differences in nosocomial infection [6.1%(2/33) vs. 17.6%(6/34), P>0.05] and intestinal function recovery time[(69.3±9.5) h vs. (70.1±11.6) h, P>0.05] between the two groups. However, the length of hospital stay [(17±3.8) d vs. (21±4.2) d, P<0.05] was significantly shorter in the treatment group. CONCLUSION:
|
Authors | Feng Shao, Cheng-gang Yang, Xin Liu, Dao-gui Yang |
Journal | Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
(Zhonghua Wei Chang Wai Ke Za Zhi)
Vol. 15
Issue 5
Pg. 476-9
(May 2012)
ISSN: 1671-0274 [Print] China |
PMID | 22648843
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
|
Chemical References |
|
Topics |
- Adult
- Aged
- Diabetes Mellitus
(therapy)
- Enteral Nutrition
(methods)
- Female
- Fish Oils
(therapeutic use)
- Gastrointestinal Neoplasms
(complications, therapy)
- Glutamine
(therapeutic use)
- Humans
- Male
- Middle Aged
- Postoperative Care
- Probiotics
(therapeutic use)
|