Kiamycin, a unique cytotoxic angucyclinone derivative from a marine Streptomyces sp.

Abstract

Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. The new angucyclinone derivative showed inhibitory activities against the human cell lines HL-60 (leukemia), A549 (lung adenocarcinoma), and BEL-7402 (hepatoma) with inhibition rates of 68.2%, 55.9%, and 31.7%, respectively, at 100 µM. It appears to have potential as an anticancer agent with selective activity.

• Authors: Zeping Xie, Bing Liu, Hongpeng Wang, Shengxiang Yang, Hongyu Zhang, Yipeng Wang, Naiyun Ji, Song Qin, Hartmut Laatsch
• Journal: Marine drugs (Mar Drugs) Vol. 10 Issue 3 Pg. 551-558 (Mar 2012) ISSN: 1660-3397 [Electronic] Switzerland
• PMID: 22611353 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthraquinones
• Antibiotics, Antineoplastic
• angucyclinone
• kiamycin

Topics

• Anthraquinones (isolation & purification, pharmacology)
• Antibiotics, Antineoplastic (isolation & purification, pharmacology)
• Aquatic Organisms
• Cell Line, Tumor
• Chromatography, Thin Layer
• Drug Screening Assays, Antitumor
• Fermentation
• HL-60 Cells
• Humans
• Magnetic Resonance Spectroscopy
• Molecular Conformation
• Seawater
• Spectrophotometry, Ultraviolet
• Streptomyces (metabolism)