Effects of vitamin D supplementation on markers of vascular function after myocardial infarction--a randomised controlled trial.

Abstract

BACKGROUND:

Low vitamin D levels are common, and are associated with a higher incidence of future vascular events. We tested whether vitamin D supplementation could improve endothelial function and other markers of vascular function in patients with a history of myocardial infarction.

METHODS:

Parallel group, placebo-controlled, double-blind randomised trial. Patients with a history of myocardial infarction were randomised to receive 100,000 units of oral vitamin D3 or placebo at baseline, 2 months and 4 months. Outcomes were measured at baseline, 2 and 6 months. Reactive hyperaemia index on fingertip plethysmography was the primary outcome. Secondary outcome measures included blood pressure, cholesterol, C-reactive protein, von Willebrand factor, tumour necrosis factor alpha, E-selectin, B-type natriuretic peptide, thrombomodulin and 25-hydroxyvitamin D levels.

RESULTS:

75 patients were randomised, mean age 66 years. 74/75 (99%) completed 6 month follow-up. 25 hydroxyvitamin D levels increased in the intervention group relative to placebo (+13 vs +1 nmol/L, p=0.04). There was no between-group difference in change in reactive hyperaemia index between baseline and 6 months (-0.18 vs -0.07, p=0.40). Of the secondary outcomes, only C-reactive protein showed a significant decline in the intervention arm relative to placebo at 6 months (-1.3 vs 2.0mg/L, p=0.03). Systolic blood pressure (+1.4 vs +2.3 mmHg, p=0.79), diastolic blood pressure (+2.0 vs +0.8 mmHg, p=0.54) and total cholesterol (+0.26 vs +0.24 mmol/L, p=0.88) showed no between-group difference at 6 months.

CONCLUSIONS:

Supplementation with vitamin D did not improve markers of vascular function in patients with a history of myocardial infarction.

• Authors: Miles D Witham, Fiona J Dove, Faisel Khan, Chim C Lang, Jill J F Belch, Allan D Struthers
• Journal: International journal of cardiology (Int J Cardiol) Vol. 167 Issue 3 Pg. 745-9 (Aug 10 2013) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 22459388 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Biomarkers
• Vitamin D
• Cholesterol

Topics

• Aged
• Biomarkers (blood)
• Blood Pressure (drug effects, physiology)
• Cholesterol (blood)
• Dietary Supplements
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Myocardial Infarction (blood, drug therapy)
• Vitamin D (pharmacology, therapeutic use)