Vitamin d status and indices of bone turnover in older European adults.

Abstract

An increased rate of bone turnover increases risk of osteoporotic fracture later in life. The concentration of 25-hydroxyvitamin D that contributes to an elevated rate of bone turnover in older adults is unclear. The objective of this study was to investigate the associations between 25-hydroxyvitamin D and biochemical markers of bone turnover in an older, pan-European cohort. 25-hydroxyvitamin D and serum markers of bone-formation (osteocalcin and bone-specific alkaline phosphatase) were assessed by ELISA, while urinary markers of bone-resorption (pyridinoline and deoxypyridinoline) were assessed by HPLC. Six percent, 36 %, and 64 % of subjects had 25-hydroxyvitamin D concentrations < 25, < 50, and < 80 nmol/L throughout the year, respectively. 25-hydroxyvitamin D was significantly and inversely correlated with serum bone-specific alkaline phosphatase (r = 0.119; p = 0.022) and urinary pyridinoline (r = 0.207; p < 0.0001) and deoxypyridinoline (r = 0.230; p < 0.0001). Stratification on the basis of tertiles [T] of 25-hydroxyvitamin D (< 47.6 [T(1)]; 47.6 - 85.8 [T₂]; > 85.8 [T₃] nmol/L), showed that urinary pyridinoline and deoxypyridinoline were significantly lower in subjects in the 2(nd) and 3(rd) compared to the 1(st) tertile (p < 0.015). Low vitamin D status (< 50 nmol/L) was associated with an increased rate of bone turnover in this older pan-European cohort.

• Authors: Kelly M Seamans, Tom R Hill, Lisa Scully, Nathalie Meunier, Maude Andrillo-Sanchez, Angela Polito, Isabelle Hininger-Favier, Donatella Ciarapica, Elizabeth E A Simpson, Barbara J Stewart-Knox, Jacqueline M O Connor, Charles Coudray, Kevin D Cashman
• Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition (Int J Vitam Nutr Res) Vol. 81 Issue 5 Pg. 277-85 (Sep 2011) ISSN: 0300-9831 [Print] Switzerland
• PMID: 22419198 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amino Acids
• Biomarkers
• Osteocalcin
• Vitamin D
• pyridinoline
• deoxypyridinoline
• 25-hydroxyvitamin D
• Alkaline Phosphatase

Topics

• Aged
• Aging (physiology)
• Alkaline Phosphatase (blood)
• Amino Acids (urine)
• Biomarkers (analysis)
• Bone Remodeling (physiology)
• Cross-Sectional Studies
• Europe
• Female
• Humans
• Male
• Middle Aged
• Osteocalcin (blood)
• Vitamin D (administration & dosage, analogs & derivatives, blood)
• Vitamin D Deficiency (complications)