Lipoprotein-associated phospholipase A2 (Lp-PLA2): a review of its role and significance as a cardiovascular biomarker.

Abstract

OBJECTIVE:

To conduct a comprehensive, systematic review of studies assessing the significance of lipoprotein-associated phospholipase A2 in cardiovascular diseases (CVDs).

MATERIAL AND METHODS:

A review of the literature was performed using the search term "Lipoprotein-associated phospholipase A2 (Lp-PLA2)" and each of the following terms: "cardiovascular risk," "cardiovascular death," "atherosclerotic disease," "coronary events," "transient ischemic attack (TIA)," "stroke," and "heart failure." The searches were performed on Medline, Google Scholar and ClinicalTrials.gov.

RESULTS:

The majority of published studies showed a significant association between Lp-PLA2 levels and cardiovascular events after multivariate adjustment. The association was consistent across a wide variety of subjects of both sexes and different ethnic backgrounds.

CONCLUSIONS:

The role of Lp-PLA2 as a significant biomarker of vascular inflammation was confirmed, and Lp-PLA2 seems to be closely correlated to cardiovascular events. It may be an important therapeutic target and may have an important role in prevention, risk stratification and personalised medicine.

• Authors: Oana Vittos, Bogdan Toana, Alexandros Vittos, Elena Moldoveanu
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 17 Issue 4 Pg. 289-302 (Jun 2012) ISSN: 1366-5804 [Electronic] England
• PMID: 22401038 (Publication Type: Journal Article, Review, Systematic Review)

Chemical References

• Biomarkers
• Inflammation Mediators
• Lipoproteins
• 1-Alkyl-2-acetylglycerophosphocholine Esterase

Topics

• 1-Alkyl-2-acetylglycerophosphocholine Esterase (metabolism, physiology)
• Biomarkers (metabolism)
• Cardiovascular Diseases (enzymology, therapy)
• Humans
• Inflammation Mediators (metabolism, physiology)
• Lipoproteins (metabolism, physiology)
• Molecular Targeted Therapy
• Oxidative Stress