Recent advances in the study on resveratrol.

Abstract

Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes and various other plants, an attractive compound to be studied. Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog 1 (SIRT1) activator, and more. Despite scepticism concerning the biological availability of resveratrol, a growing body of in vivo evidence indicates that resveratrol has protective effects in several stress and disease models. Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health.

• Authors: Rieko Nakata, Satoru Takahashi, Hiroyasu Inoue
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 35 Issue 3 Pg. 273-9 ( 2012) ISSN: 1347-5215 [Electronic] Japan
• PMID: 22382311 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cyclooxygenase Inhibitors
• Peroxisome Proliferator-Activated Receptors
• Stilbenes
• Nitric Oxide Synthase Type III
• Sirtuin 1
• Resveratrol

Topics

• Animals
• Cyclooxygenase Inhibitors (pharmacology)
• Humans
• Nitric Oxide Synthase Type III (metabolism)
• Peroxisome Proliferator-Activated Receptors (metabolism)
• Resveratrol
• Sirtuin 1 (metabolism)
• Stilbenes (pharmacology)