[Activity of glycolysis key enzymes in subcellular structures of normal kidneys and under acute renal insufficiency].

Abstract

The activity of key glycolysis enzymes (hexokinase, glucose-6-phosphatase, phosphofructokinase, fructose-diphosphatase and ketose-1-phosphate aldolase) in the kidney tissue and its subcellular structures was studied in normal rats and in rats with experimental acute renal insufficiency. It is established that considerable biochemical changes in the kidney tissues affecting all the elements of cellular structures occur under acute lesion of the kidneys. The activity of the enzymes under study under acute renal insufficiency lowers to a greater extent in those subcellular structures of the kidneys where they are mainly localized. The arising disturbances in permeability of the kidneys cellular membranes intensify the release of the mentioned enzymes to blood serum and urine, that in its turn disturbs the coordination of certain glycolysis stages.

• Authors: N M Petrun', L A Khomenko
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1979 May-Jun Vol. 51 Issue 3 Pg. 270-4 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Aktivnost' kliuchevykh fermentov glikoliza v subkletochnykh spakh pochek vnorme i pri ostroĭ pochechnoĭ nedostatochnosti.
• PMID: 223262 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Hexokinase
• Phosphofructokinase-1
• Fructose-Bisphosphatase
• Glucose-6-Phosphatase
• Fructose-Bisphosphate Aldolase

Topics

• Acute Kidney Injury (enzymology, pathology)
• Animals
• Fructose-Bisphosphatase (metabolism)
• Fructose-Bisphosphate Aldolase (metabolism)
• Glucose-6-Phosphatase (metabolism)
• Glycolysis
• Hexokinase (metabolism)
• Kidney (enzymology, pathology)
• Male
• Phosphofructokinase-1 (metabolism)
• Rats
• Subcellular Fractions (enzymology)