Compliance, safety, and effectiveness of fixed-dose artesunate-amodiaquine for presumptive treatment of non-severe malaria in the context of home management of malaria in Madagascar.
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| Abstract |
Home management of malaria is recommended for prompt, effective antimalarial treatment in children less than five years of age. Compliance, safety, and effectiveness of the new fixed-dose artesunate-amodiaquine regimen used to treat suspected malaria were assessed in febrile children enrolled in a 24-month cohort study in two settings in Madagascar. Children with fever were asked to visit community health workers. Presumptive antimalarial treatment was given and further visits were scheduled for follow-up. The primary endpoint was the risk of clinical/parasitologic treatment failure. Secondary outcomes included fever/parasite clearance, change in hemoglobin levels, and frequency of adverse events. The global clinical cure rate was 98.4% by day 28 and 97.9% by day 42. Reported compliance was 83.4%. No severe adverse effects were observed. This study provides comprehensive data concerning the clinical cure rate obtained with artesunate-amodiaquine and evidence supporting the scaling up of home management of malaria.
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| Authors | Arsène Ratsimbasoa, Harintsoa Ravony, Jeanne-Aimée Vonimpaisomihanta, Rogelin Raherinjafy, Martial Jahevitra, Rabenja Rapelanoro, Jean De Dieu Marie Rakotomanga, Denis Malvy, Pascal Millet, Didier Ménard |
| Journal | The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 86 Issue 2 Pg. 203-10 (Feb 2012) ISSN: 1476-1645 [Electronic] United States |
| PMID | 22302849 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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