Photodynamic effect in near-IR light by a photocytotoxic iron(III) cellular imaging agent.

Abstract

A red light for cancer cells: an iron(III) complex (1, see picture) that contains an anthracenyl fluorophore moiety and a catecholate ligand is a potent, metal-based PDT agent that efficiently photocleaves DNA in near-infrared light, has significant nuclear uptake, and high photocytotoxicity in red light by an apoptotic pathway in HeLa and MCF-7 cancer cells.

• Authors: Uttara Basu, Imran Khan, Akhtar Hussain, Paturu Kondaiah, Akhil R Chakravarty
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 51 Issue 11 Pg. 2658-61 (Mar 12 2012) ISSN: 1521-3773 [Electronic] Germany
• PMID: 22290597 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Ferric Compounds
• Photosensitizing Agents
• DNA

Topics

• Apoptosis (drug effects)
• Cell Line, Tumor
• Crystallography, X-Ray
• DNA (metabolism)
• DNA Cleavage
• Ferric Compounds (chemistry)
• HeLa Cells
• Humans
• Infrared Rays
• Microscopy, Confocal
• Molecular Conformation
• Neoplasms (drug therapy)
• Photochemotherapy
• Photosensitizing Agents (chemistry, therapeutic use, toxicity)