A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection.
Abstract | BACKGROUND: RESULTS: CONCLUSIONS:
|
Authors | Chung-Her Jenh, Mary Ann Cox, Long Cui, Eva-Pia Reich, Lee Sullivan, Shu-Cheng Chen, David Kinsley, Shiguang Qian, Seong Heon Kim, Stuart Rosenblum, Joseph Kozlowski, Jay S Fine, Paul J Zavodny, Daniel Lundell |
Journal | BMC immunology
(BMC Immunol)
Vol. 13
Pg. 2
(Jan 10 2012)
ISSN: 1471-2172 [Electronic] England |
PMID | 22233170
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Piperazines
- Receptors, CXCR3
- SCH 546738
- Pyrazinamide
|
Topics |
- Animals
- Arthritis, Experimental
(drug therapy, immunology)
- Arthritis, Rheumatoid
(drug therapy, immunology)
- Autoimmune Diseases
(drug therapy, immunology)
- Chemotaxis, Leukocyte
(drug effects, immunology)
- Disease Models, Animal
- Encephalomyelitis, Autoimmune, Experimental
(drug therapy, immunology)
- Graft Rejection
(immunology, prevention & control)
- Graft Survival
(drug effects)
- Heart Transplantation
- Humans
- In Vitro Techniques
- Mice
- Multiple Sclerosis
(drug therapy, immunology)
- Piperazines
(pharmacology)
- Protein Binding
- Pyrazinamide
(analogs & derivatives, pharmacology)
- Radioligand Assay
- Rats
- Receptors, CXCR3
(antagonists & inhibitors)
- T-Lymphocytes
(drug effects, immunology)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|