Abstract | BACKGROUND/AIM: PATIENTS AND METHODS: Tissue sections from 82 breast cancer cases clustered according to histological grade, lymph node (LN) and hormone receptor (HR) status were assessed by immunohistochemistry for RXRα and PPARγ. RESULTS: RXRα was found to be strongly and moderately expressed in 11 (14.10%) and 33 (42.31%) cases, respectively. PPARγ was found to be strongly and moderately expressed in 33 (41.25%) and 25 (31.25%) cases, respectively. Only RXRα expression was inversely correlated with histological grade. Surprisingly, significantly elevated PPARγ expression was found in cases with positive LN status. Survival analysis did not yield significant results. CONCLUSION: Our data support the current thesis of RXRα being a potential target for feature molecular interventions.
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Authors | N Ditsch, T Vrekoussis, M Lenhard, I Rühl, J Gallwas, T Weissenbacher, K Friese, D Mayr, A Makrigiannakis, U Jeschke |
Journal | In vivo (Athens, Greece)
(In Vivo)
2012 Jan-Feb
Vol. 26
Issue 1
Pg. 87-92
ISSN: 1791-7549 [Electronic] Greece |
PMID | 22210720
(Publication Type: Journal Article)
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Chemical References |
- PPAR gamma
- Receptors, Estrogen
- Receptors, Progesterone
- Retinoid X Receptor alpha
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Topics |
- Breast Neoplasms
(metabolism, pathology)
- Disease-Free Survival
- Female
- Follow-Up Studies
- Humans
- Immunohistochemistry
- Lymph Nodes
(pathology)
- Neoplasm Grading
- PPAR gamma
(biosynthesis)
- Receptors, Estrogen
(metabolism)
- Receptors, Progesterone
(metabolism)
- Retinoid X Receptor alpha
(biosynthesis)
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