Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells.

Abstract	Cadmium is a typical environmental pollutant and the causative agent of itai-itai disease. Ubiquitin ligases potentially involved in mediating the effects of cadmium toxicity were investigated by RNA interference using a panel of small inhibitory (si)RNAs. The results demonstrated that the inhibition of gene expression of FBXO6 sensitizes HEK293 cells to cadmium.
Authors	Gi-Wook Hwang, Ke Du, Tsutomu Takahashi, Akira Naganuma
Journal	The Journal of toxicological sciences (J Toxicol Sci) Vol. 36 Issue 6 Pg. 847-9 ( 2011) ISSN: 1880-3989 [Electronic] Japan
PMID	22129750 (Publication Type: Journal Article)
Chemical References	Environmental Pollutants RNA, Small Interfering Cadmium FBXO6 protein, human SKP Cullin F-Box Protein Ligases
Topics	Cadmium (toxicity) Cell Survival (drug effects) Environmental Pollutants (toxicity) Gene Expression (drug effects) HEK293 Cells Humans RNA Interference RNA, Small Interfering (genetics) Real-Time Polymerase Chain Reaction SKP Cullin F-Box Protein Ligases (genetics) Transfection

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