N-terminal pro-B-type natriuretic peptide and long-term mortality in non-ischaemic cardiomyopathy.

Abstract

AIM:

The inactive N-terminal fragment of B-type natriuretic peptide is a strong predictor of mortality among patients with acute and chronic heart failure secondary to ischaemic heart disease. Its prognostic utility in patients with non-ischaemic heart disease is not well established. We therefore assessed the relationship of N-terminal proBNP levels and long-term mortality in patients with non-ischaemic cardiomyopathy.

METHODS:

N-terminal proBNP was measured in serum samples of 156 patients who presented to a single academic centre with worsening heart failure secondary to non-ischaemic cardiomyopathy. The rate of death from all causes was determined after a mean follow-up of 8.9 years.

RESULTS:

Multivariate analyses, using Cox proportional hazards models, established NT-proBNP and left ventricular diastolic diameter as predictors for cardiac mortality with estimated hazard ratios of 2.76 (95% confidence interval: 1.53, 4.98) and 1.06 (95% confidence interval: 1.02, 1.10), respectively.

CONCLUSION:

This to date longest-term analysis of N-terminal proBNP and mortality in patients with proven non-ischaemic cardiomyopathy confirms this cardiac-specific biomarker as powerful, independent risk predictor. It is a superior prognostic determinant to New York Heart Association functional class and left ventricular ejection fraction.

• Authors: Florian Krackhardt, Hans-Dirk Düngen, Tobias Daniel Trippel, Simone Inkrot, Verena Tscholl, Peter Schlattmann, Kathrin Kehrt, Wilhelm Haverkamp
• Journal: Wiener klinische Wochenschrift (Wien Klin Wochenschr) Vol. 123 Issue 23-24 Pg. 738-42 (Dec 2011) ISSN: 1613-7671 [Electronic] Austria
• PMID: 22105112 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Peptide Fragments
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Biomarkers (blood)
• Cardiomyopathies (blood, diagnosis, mortality)
• Comorbidity
• Female
• Germany (epidemiology)
• Humans
• Male
• Middle Aged
• Myocardial Ischemia (blood, diagnosis, mortality)
• Natriuretic Peptide, Brain (blood)
• Peptide Fragments (blood)
• Prevalence
• Reproducibility of Results
• Risk Assessment (methods)
• Risk Factors
• Sensitivity and Specificity
• Survival Analysis
• Survival Rate
• Ventricular Dysfunction, Left (blood, diagnosis, mortality)