Abstract | BACKGROUND: OBJECTIVE: We evaluated the feasibility of endoscopic submucosal dissection (ESD) using sodium alginate. SETTING AND INTERVENTIONS: MAIN OUTCOME MEASUREMENT: The lesion-lifting properties of sodium alginate and clinical outcomes were assessed. RESULTS: The thickness of the submucosal elevation created by 3% sodium alginate in porcine stomach was equivalent to that of sodium hyaluronate. ESD using sodium alginate was completed successfully in all patients without adverse effects except in 1 patient in whom transient shrinkage of the gastric wall disappeared spontaneously after approximately 30 minutes. The mean tumor size was 15.3 mm. En bloc resection and a negative resection margin were obtained in all. Histopathologic examination revealed that all tumors were confined to the mucosal layer except for 1 that was confined to the submucosal layer without lymphovascular invasion, and there were no adverse effects such as tissue damage. No patient required additional treatment, and none showed recurrence during a median follow-up period of 28 months. LIMITATIONS: Small sample size. CONCLUSION: This preliminary study suggests that sodium alginate might be a novel, safe submucosal injection material for use in endoscopic resection. Further investigation of the properties of sodium alginate is warranted.
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Authors | Tomonori Akagi, Kazuhiro Yasuda, Masaaki Tajima, Kosuke Suzuki, Masafumi Inomata, Norio Shiraishi, Yuhki Sato, Seigo Kitano |
Journal | Gastrointestinal endoscopy
(Gastrointest Endosc)
Vol. 74
Issue 5
Pg. 1026-32
(Nov 2011)
ISSN: 1097-6779 [Electronic] United States |
PMID | 22032316
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved. |
Chemical References |
- Alginates
- Biocompatible Materials
- Hexuronic Acids
- Glucuronic Acid
|
Topics |
- Adenocarcinoma
(pathology, surgery)
- Adenoma
(pathology, surgery)
- Aged
- Alginates
(administration & dosage)
- Animals
- Biocompatible Materials
(administration & dosage)
- Dissection
- Female
- Gastric Mucosa
(pathology, surgery)
- Glucuronic Acid
(administration & dosage)
- Hexuronic Acids
(administration & dosage)
- Humans
- Injections
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(diagnosis)
- Stomach Neoplasms
(pathology, surgery)
- Swine
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