[News on antithrombotic therapy and pregnancy].

Abstract

OBJECTIVES:

State of the art of antithrombotics and their use recommendations during pregnancy.

METHODS:

A review

RESULTS:

Aspirin and heparins remain the safest molecules during pregnancy, and oral anticoagulants are still used for mechanical valves. Heparinoids are the methods of choice in case of heparin-induced thrombopenia but other molecules could find their place: fondaparinux at first and possibly the direct thrombin inhibitors. Thrombolysis may be used in case of life-threatening incident. At present, the new oral forms can not be used during pregnancy

CONCLUSIONS:

During pregnancy, all antithrombotics, except the oral forms, can be used, but the low molecular weight heparins replacing the unfractionated ones in the treatment and prevention of venous thromboembolism remain the treatment of choice.

• Authors: Céline Chauleur, Jean-Christophe Gris, Pierre Seffert, Patrick Mismetti
• Journal: Therapie (Therapie) 2011 Sep-Oct Vol. 66 Issue 5 Pg. 437-43 ISSN: 0040-5957 [Print] France
• Vernacular Title: Mise au point sur les antithrombotiques et la grossesse.
• PMID: 22031688 (Publication Type: English Abstract, Journal Article, Review)
• Copyright: © 2011 Société Française de Pharmacologie et de Thérapeutique.

Chemical References

• Fibrinolytic Agents
• Folic Acid Antagonists
• Vitamin K
• Heparin
• Thrombin
• Factor Xa
• Aspirin

Topics

• Adult
• Aspirin (administration & dosage, adverse effects, therapeutic use)
• Factor Xa (adverse effects)
• Female
• Fibrinolytic Agents (administration & dosage, adverse effects, therapeutic use)
• Folic Acid Antagonists (adverse effects)
• Heparin (administration & dosage, adverse effects, therapeutic use)
• Humans
• Pregnancy
• Pregnancy Complications (drug therapy)
• Pregnancy Trimester, Third (physiology)
• Thrombin (antagonists & inhibitors)
• Thrombolytic Therapy
• Venous Thromboembolism (drug therapy)
• Vitamin K (antagonists & inhibitors)